The two sides had played a T-20 series which ended up in a draw
One-day international series between Ireland and USA got cancelled after the members of the touring staff tested positive for Covid-19.
The two teams had played a Twenty20 series which ended 1-1 while the ODI series in Florida was interrupted by coronavirus cases first detected amongst the USA squad and umpires.
Ireland won the second T-20 match against the hosts on December 24. Ireland set a target of 150 runs which the hosts failed to chase down. USA lost the match by 9 runs. The hosts managed to score 141 runs with a loss of 7 wickets in 20 overs.
"While all players in both current playing squads have returned negative COVID results overnight, two members of the Irish support staff have tested positive, as well as several partners of players, resulting in two of the Irish players being deemed as 'close contacts'," the two boards said in a statement.
"As such the risks and concerns about further spread have meant that both Boards have regrettably agreed to cancel the remaining two scheduled matches."
Ireland's visit to USA was the first time that the United States had hosted an International Cricket Council (ICC) full member nation.
Cricket has grown rapidly in America for the past decade. The US is now home to an estimated 30 million cricket fans.
Ireland is scheduled to tour the Caribbean to face the West Indies in three ODIs and one T20I in January. They will fly to Kingston, Jamaica on Friday but the two members who tested positive will complete their isolation in Florida.
"From a broader perspective, consideration had to be given to the current series as well as the second leg of our tour," Cricket Ireland's high-performance director Richard Holdsworth said.
"We need to be mindful of travel requirements for entering Jamaica and meeting Cricket West Indies COVID protocols."
The Brief. Sign up to receive the top stories you need to know right now.